Protocol for a multi-country retrospective observational paediatric sepsis epidemiological study (SENTINEL International)

Abstract

Introduction Improving outcomes from sepsis in children is a WHO Global Health Priority, yet mortality from sepsis remains high, particularly in low- and middle-income countries (LMICs). This database from children with community-acquired childhood sepsis in LMICs and some high-income countries will allow analysis of the burden of disease, including incidence, severity and outcomes. Understanding these aspects of sepsis care is fundamental for the design and conduct of future international interventional trials to improve childhood sepsis outcomes. Methods and analysis This multicountry retrospective observational study will include children up to 18 years of age presenting to emergency depa..